Multiparametric Guided-Mode Resonance Biosensor Monitoring Bulk and Surface-Film Variations

A guided-mode resonance (GMR) sensor with multiple resonant modes is used to measure the collection of biomolecules on surface and index refraction environment (bulk). The number variables that can be monitored (biolayer refraction, biolayer thickness, bulk, or background, refraction) determined by supported are sensitive changes in these variable values. we use has a grating homogeneous layer, both which made silicon nitride (Si3N4), quartz substrate. In this work, simulate reflection response as grows at thicknesses from 0 20 nm indices 1.334 1.43 RIU; simultaneously, vary bulk RIU. specified span values, wavelength shifts for 2023 permutations calculated accurately inverted. Inversion process taking shifts, sensor, input, finding quantitative variation output. Analysis spectral data performed programmatically MATLAB. Using experimentally measured values determined. model experiment, deposit Concanavalin (Con A) our subsequently yeast, preferentially bonds Con A. unique contribution work thickness simultaneously